US Patent Number
The present disclosure relates to a sodium iodide symporter (NIS)-repressor binding site (NRBS) consisting of a DNA molecule spanning from −645 to −605 nucleotides (SEQ ID NO:4) or from −648 to −620 nucleotides (SEQ ID NO:5) upstream from the translation start site of human NIS gene. The disclosure further relates to a method of restoring iodide transport to a human thyroid carcinoma cell, including: the steps of: i) contacting the cell expressing and forming a NIS repressor protein complex capable of binding to the NRBS of the disclosure with a modulator of said complex, and ii) administering to the cell radiolabeled iodide.
University of Kentucky Research Foundation, Lexington, KY (US)
Ain, Kenneth B. and Li, Wei, "Transcriptional Repression of Sodium-Iodide Symporter in Thyroid Carcinoma" (2012). Internal Medicine Faculty Patents. 1.