Year of Publication

2006

Document Type

Thesis

College

Graduate School

Department

Biomedical Engineering

First Advisor

Eugene Bruce

Abstract

We hypothesized that temporal features of EEG are altered in sleep apnea subjects comparedto normal subjects. The initial aim was to develop a measure to discriminate sleep stages innormals. The longer-term goal was to apply these methods to identify differences in EEGactivity in sleep apnea subjects from normals. We analyzed the C3A2 EEG and anelectrooculogram (EOG) recorded from 9 normal adults awake and in rapid eye movement(REM) and non-REM sleep. The EEG signals were filtered to remove EOG contamination. Twomeasures of the irregularity of EEG signals, Sample Entropy (SpEn) and Tsallis Entropy, wereevaluated for their ability to discriminate sleep stages. SpEn changes with sleep state, beinglargest in Wake. Stage 3/4 had the smallest SpEn (0.57??0.11) normalized to Wake values,followed by Stage 2 (0.72??0.09), REM (0.75??0.1) and Stage 1 (0.89??0.05). This pattern wasconsistent in all the polysomnogram records analyzed. Similar pattern was observed in leadO1A2 as well. We conclude that SpEn may be useful as part of a montage for assessing sleepstate. We analyzed data from sleep apnea subjects having obstructive and central apnea eventsand have made some preliminary observations; the SpEn values were more similar across sleepstages and also high correlation with oxygen saturation was observed.

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