The Toxicology Investigators Consortium Case Registry—the 2019 Annual Report


The Toxicology Investigators Consortium (ToxIC) Registry was established by the American College of Medical Toxicology (ACMT) in 2010. The Registry collects data from participating sites with the agreement that all bedside medical toxicology consultation will be entered. This tenth annual report summarizes the Registry's 2019 data and activity with its additional 7177 cases. Cases were identified for inclusion in this report by a query of the ToxIC database for any case entered from 1 January to 31 December 2019. Detailed data was collected from these cases and aggregated to provide information which included demographics, reason for medical toxicology evaluation, agent and agent class, clinical signs and symptoms, treatments and antidotes administered, mortality, and whether life support was withdrawn. 50.7% of cases were female, 48.5% were male, and 0.8% were transgender. Non-opioid analgesics was the most commonly reported agent class, followed by opioid and antidepressant classes. Acetaminophen was once again the most common agent reported. There were 91 fatalities, comprising 1.3% of all Registry cases. Major trends in demographics and exposure characteristics remained similar to past years' reports. Sub-analyses were conducted to describe exposures in cases of self-harm, gender differences in substance use disorder, and trends in addiction medicine and pain management consultations.

Document Type


Publication Date


Notes/Citation Information

Published in Journal of Medical Toxicology, v. 16, issue 4.

Copyright © American College of Medical Toxicology 2020, corrected publication 2021

Digital Object Identifier (DOI)

Funding Information

The Toxicology Investigators Consortium received funding from the US National Institute of Drug Abuse 1RO1DA037317-02 and data-sharing contracts with the U.S. Food and Drug Administration and BTG International, Inc. (North America).