We examined the pharmacokinetic properties of vancomycin conjugated to a bone-targeting agent (BT) with high affinity for hydroxyapatite after systemic intravenous administration. The results confirm enhanced persistence of BT-vancomycin in plasma and enhanced accumulation in bone relative to vancomycin. This suggests that BT-vancomycin may be a potential carrier for the systemic targeted delivery of vancomycin in the treatment of bone infections, potentially reducing the reliance on surgical debridement to achieve the desired therapeutic outcome.
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This study was supported by funding from Pradama, Inc., to W.M.P. and a Department of Defense Peer-Reviewed Orthopaedic Research Program Expansion Award (W81XWH-15-1-0716) to M.S.S. and P.A.C.
Albayati, Zaineb A. F.; Sunkara, Manjula; Schmidt-Malan, Suzannah M.; Karau, Melissa J.; Morris, Andrew J.; Steckelberg, James M.; Patel, Robin; Breen, Philip J.; Smeltzer, Mark S.; Taylor, K. Grant; Merten, Kevyn E.; Pierce, William M.; and Crooks, Peter A., "Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone" (2016). Saha Cardiovascular Research Center Faculty Publications. 25.