A novel crosslinker [4,4′-dihydroxybiphenyl diacrylate (44BDA)] was developed, and a series of temperature-responsive hydrogels were synthesized through free radical polymerization of N-isopropylacrylamide (NIPAAm) with 44BDA. The temperature-responsive behavior of the resulting gels was characterized by swelling studies, and the lower critical solution temperature (LCST) of the hydrogels was characterized through differential scanning calorimetry. Increased content of 44BDA led to a decreased swelling ratio and shifted the LCST to lower temperatures. These novel hydrogels also displayed resiliency through multiple swelling–deswelling cycles, and their temperature responsiveness was reversible. The successful synthesis of NIPAAm-based hydrogels crosslinked with 44BDA has led to a new class of temperature-responsive hydrogel systems with a variety of potential applications.
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This research has been generously supported by the NSF-REU grant EEC-1460486 and the NIEHS/NIH grant P42ES007380.
The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acsomega.7b01247.
Tang, Shuo; Floy, Martha; Bhandari, Rohit; Sunkara, Manjula; Morris, Andrew J.; Dziubla, Thomas D.; and Hilt, J. Zach, "Synthesis and Characterization of Thermoresponsive Hydrogels Based on N-Isopropylacrylamide Crosslinked with 4,4′-Dihydroxybiphenyl Diacrylate" (2017). Chemical and Materials Engineering Faculty Publications. 36.