US Patent Number

5036097

Publication Date

7-30-1991

Abstract

Compositions containing PBN, or active derivatives thereof, in a suitable pharmaceutical carrier for administration to a patient, are disclosed for treating or preventing gastric ulceration caused by ingestion of non-steroidal anti-inflammatories. Based on animal studies, the dosage is in the range of 3 to 300 mg/kg and is administered prior to, simultaneously, or shortly after ingestion of the NSAID compound(s). In the preferred embodiment, the range is between 10 and 30 mg/kg, depending on the dosage unit required to protect the mucosa. The preferred method of administration is orally, alone or in combination with the non-steroidal anti-inflammatory. It is believed that the PBN is also useful alone for treatment or prevention of ulcers, aspects of diarrhea, gastritis, esophagitis, ileitis, and as an analgesic.

Assignees

Oklahoma Medical Research Foundation, Oklahoma City, Okla., University of Kentucky Research Foundation, Lexington, Ky.

Application Number

491,452

Filing Date

03/09/1990

Notes

This patent was reissued as:

Patent No.: Re. 35213
Issued: Apr. 16, 1996
Appl. No.: 97,998
Filed: Jul. 29, 1993

Click here to access Patent No. Re. 35213

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