Date Available
12-7-2011
Year of Publication
2004
Degree Name
Master of Science (MS)
Document Type
Thesis
College
Graduate School
Department
Biomedical Engineering
First Advisor
Dr. Charles F. Knapp
Second Advisor
Dr. David Randall
Abstract
Cardiovascular control in the human is significantly impaired after spinal cord injury(SCI) having a direct effect on the sympathetic nervous system (SNS) causing an inability toregulate vasoconstriction below the level of the lesion. The effects of SCI on the two majorcomponents of blood pressure regulation, control of plasma volume and neural control of theheart and peripheral vasculature are poorly understood. In particular, no index to diagnosedisorders to autonomic control of the heart and vasculature has been developed. The presentstudy primarily utilized noninvasively acquired, easily accessible variables that may havepromise as indicators of autonomic activity for assessing the level of autonomic injury andrecovery of visceral control following SCI. The most significant results and the clearestdifferences between the three groups (able-bodied, paraplegic and tetraplegic) were evident inspectral analysis obtained in the frequency domain: Arterial blood pressure and lower body (at aregion on the shin) skin perfusion spectral power in the low frequency (LF) region are ofsignificance. These variables could be good discriminators of the three groups, as well as showlevel of SCI and autonomic function.
Recommended Citation
Hogancamp II, Charles Everett, "Loss of Sympathetic Control of Cardiovascular Function Following Spinal Cord Injury" (2004). University of Kentucky Master's Theses. 198.
https://uknowledge.uky.edu/gradschool_theses/198
