Date Available
10-1-2013
Year of Publication
2013
Degree Name
Master of Chemical Engineering (MChE)
Document Type
Master's Thesis
College
Engineering
Department/School/Program
Chemical and Materials Engineering
First Advisor
Dr. Kimberly Anderson
Abstract
Systemic inflammation involves a complex array of cytokines that can result in organ dysfunction. Mortality remains high despite the vast amount of research conducted to find an effective biomarker. The cause of systemic inflammation can be broad and non-specific; therefore, this research investigates using transendothelial electrical resistance (TEER) measurements to better define systemic inflammatory response syndrome (SIRS)/sepsis within a patient. Results show a difference in TEER measurements between healthy individuals and SIRS-rated patients. This research also displays correlations between TEER measurements and biomarkers currently studied with systemic inflammation (tumor necrosis factor-α, C- reactive protein, procalcitonin). Furthermore, this research also presents the groundwork for developing a microfluidic cell-based biosensor using low temperature co-fired ceramic materials. An LTCC TEER-based microfluidic device has the potential to aid in a more effective treatment strategy for patients and potentially save lives.
Recommended Citation
Mercke, William L., "Diagnosis of Systemic Inflammation Using Transendothelial Electrical Resistance and Low-Temperature Co-fired Ceramic Materials" (2013). Theses and Dissertations--Chemical and Materials Engineering. 21.
https://uknowledge.uky.edu/cme_etds/21
Included in
Biology and Biomimetic Materials Commons, Biomedical Devices and Instrumentation Commons, Ceramic Materials Commons
