Abstract

Exposure to certain per-and polyfluoroalkyl substances (PFAS) has been shown to be positively associated with total and/or low-density lipoprotein cholesterol. Examining this association in lipid lowering interventions may provide additional evidence linking PFAS to cardiovascular risk. We examined the relationship of 6 PFAS with cholesterol in a 6-month lifestyle-based intervention. We quantitated PFAS in 350 individuals at baseline and post intervention and examined associations of PFAS with cholesterol before and after intervention. Food frequency questionnaires and GIS analyses were used to investigate PFAS hotspots and possible exposure routes. Cholesterol significantly decreased following intervention and in parallel, PFOS, PFOA, PFHxS, and PFHpA significantly decreased. PFOS was positively correlated with total cholesterol only post-intervention. We observed that PFOS was distributed among both non-albumin and albumin lipoprotein fractions pre-intervention, but entirely in albumin fraction post-intervention. Our results indicate that lipid-lowering via lifestyle modification may impact on circulating levels or distribution of PFAS.

Document Type

Article

Publication Date

3-2023

Notes/Citation Information

1382-6689/© 2023 Elsevier B.V. All rights reserved.

Digital Object Identifier (DOI)

https://doi.org/10.1016/j.etap.2023.104062

Funding Information

This research was supported in part by the National Institute of Environmental Health Sciences [P30ES020957, P30ES026529, R00ES028734], the Office of the Vice President for Research at Wayne State University, Health Resources and Services Administration, D1ARH20134, and used resources at the Lexington, KY VA medical center. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

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