Abstract
Respiratory interoception is one of the internal bodily systems that is comprised of different types of somatic and visceral sensations elicited by different patterns of afferent input and respiratory motor drive mediating multiple respiratory modalities. Respiratory interoception is a complex system, having multiple afferents grouped into afferent clusters and projecting into both discriminative and affective centers that are directly related to the behavioral assessment of breathing. The multi-afferent system provides a spectrum of input that result in the ability to interpret the different types of respiratory interceptive sensations. This can result in a response, commonly reported as breathlessness or dyspnea. Dyspnea can be differentiated into specific modalities. These respiratory sensory modalities lead to a general sensation of an Urge-to-Breathe, driven by a need to compensate for the modulation of ventilation that has occurred due to factors that have affected breathing. The multiafferent system for respiratory interoception can also lead to interpretation of the sensory signals resulting in respiratory related sensory experiences, including the Urge-to-Cough and Urge-to-Swallow. These behaviors are modalities that can be driven through the differentiation and integration of multiple afferent input into the respiratory neural comparator. Respiratory sensations require neural somatic and visceral interoceptive elements that include gated attention and detection leading to respiratory modality discrimination with subsequent cognitive decision and behavioral compensation. Studies of brain areas mediating cortical and subcortical respiratory sensory pathways are summarized and used to develop a model of an integrated respiratory neural network mediating respiratory interoception.
Document Type
Article
Publication Date
6-2024
Digital Object Identifier (DOI)
https://doi.org/10.1016/j.autneu.2024.103181
Funding Information
The study was supported by NSTC 112-2320-B-182-010-MY3 from the National Science & Technology Council and BMRPB96 from the Linkou Chang Gung Memorial Hospital in Taiwan.
Repository Citation
Chan, Pei-Ying Sarah; Lee, Lu-Yuan; and Davenport, Paul W., "Neural mechanisms of respiratory interoception" (2024). UK CARES Faculty Publications. 53.
https://uknowledge.uky.edu/ukcares_facpub/53
Included in
Endocrine System Commons, Molecular and Cellular Neuroscience Commons, Neurology Commons
Notes/Citation Information
1566-0702/© 2024 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by- nc-nd/4.0/).