Abstract
The incidence of in utero drug exposure (IUDE) and neonatal extracorporeal membrane oxygenation (ECMO) utilization have both increased over the past decade. However, there are no studies to date that examine the impact that IUDE has on neonates requiring ECMO. In this retrospective cohort study, we compared the clinic course and outcomes of neonates who were placed on ECMO with IUDE vs. neonates without IUDE. Analysis included data extracted from medical records from all neonatal ECMO runs between January 2014 and January 2021 at the University of Kentucky Children’s Hospital. A total of 56 neonatal patients were placed on ECMO during this time period and there were a total of 57 ECMO runs. Nearly one-third of neonates (16) had documented IUDE. There were no differences in gestational age, length of ECMO run, survival to discharge, or number of major complications while on ECMO in the neonates with IUDE compared to those without. In contrast, greater use of sedative and analgesic adjuvant medications during ECMO was required for IUDE-ECMO cases ( p < 0.01). Trending results indicated that post-ECMO feeding complications and total hospitalization length were also greater in the IUDE- ECMO group. These findings illustrate the complex influence of prenatal drug exposures on neonatal patient care and warrant the development of clinical care strategies optimized for this unique patient group.
Document Type
Article
Publication Date
3-2023
Digital Object Identifier (DOI)
https://doi.org/10.3389/fped.2023.1020716
Funding Information
The Department of Pediatrics at the University of Kentucky has paid the cost of publication.
Repository Citation
Walther, Hallie; Schadler, Aric; Garlitz, Karen; Bauer, John Anthony; Kohler, Lindsay; Waldsmith, Erika; and Ballard, Hubert O., "Impact of in utero drug exposure on neonates requiring ECMO: A retrospective cohort study" (2023). UK CARES Faculty Publications. 104.
https://uknowledge.uky.edu/ukcares_facpub/104
Notes/Citation Information
© 2023 Walther, Schadler, Garlitz, Bauer, Kohler, Waldsmith and Ballard. This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.