Abstract
Prostate cancer occurs frequently in men and can often lead to death. Many cancers, including prostate cancer, can be initiated by oxidative insult caused by free radicals and reactive oxygen species. The superoxide dismutase family removes the oxygen-derived reactive oxygen species, and increased superoxide dismutase activity can often be protective against prostate cancer. Prostate cancer can be treated in a variety of ways, including surgery, androgen deprivation therapy, radiation therapy, and chemotherapy. The clinical trajectory of prostate cancer varies from patient to patient, but more aggressive tumors often tend to be radioresistant. This is often due to the free-radical and reactive-oxygen-species-neutralizing effects of the superoxide dismutase family. Superoxide dismutase 2, which is especially important in this regard, can be induced by the NF-κB pathway, which is an important mechanism in radioresistance. This information has enabled the development of interventions that manipulate the NF-κB mechanism to treat prostate cancer.
Document Type
Review
Publication Date
11-30-2021
Digital Object Identifier (DOI)
https://doi.org/10.3390/antiox10121925
Repository Citation
Kumar, Sameera and St. Clair, Daret, "Radioresistance in Prostate Cancer: Focus on the Interplay between NF-κB and SOD" (2021). Toxicology and Cancer Biology Faculty Publications. 107.
https://uknowledge.uky.edu/toxicology_facpub/107
Notes/Citation Information
Published in: Antioxidants, v. 10, issue 12, 1925.
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).