Hybrid Diffuse Optical Techniques for Continuous Hemodynamic Measurement in Gastrocnemius During Plantar Flexion Exercise
Occlusion calibrations and gating techniques have been recently applied by our laboratory for continuous and absolute diffuse optical measurements of foreann muscle hemodynamics during handgrip exercises. The translation of these techniques from the foreann to the lower limb is the goal of this study as various diseases preferentially affect muscles in the lower extremity. This study adapted a hybrid near-infrared spectroscopy and diffuse correlation spectroscopy system with a gating algorithm to continuously quantify hemodynamic responses of medial gastrocnemius during plantar flexion exercises in 10 healthy subjects. The outcomes from optical measurement include oxy-, deoxy-, and total hemoglobin poncentrations, blood oxygen ~aturation, and relative changes in blood flow (rBF) and oxygen consumption rate (rV02) . We calibrated rBF and rV02 profiles with absolute baseline values of BF and V02 obtained by venous and arterial occlusions, respectively. Results from this investigation were comparable to values from similar studies. Additionally, significant correlation was observed between resting local muscle BF measured by the optical technique and whole limb BF measured concurrently by a strain gauge venous plethysmography. The extensive hemodynamic and metabolic profiles during exercise will allow for future comparison studies to investigate the diagnostic value of hybrid technologies in muscles affected by disease.
Digital Object Identifier (DOI)
We thank the National Institutes of Health for support from R2 1-AG034279 and R21-AG046762.
Henry, Brad; Zhao, Mingjun; Shang, Yu; Uhl, Tim L.; Thomas, D. Travis; Xenos, Eleftherios S.; Saha, Sibu P.; and Yu, Guoqiang, "Hybrid Diffuse Optical Techniques for Continuous Hemodynamic Measurement in Gastrocnemius During Plantar Flexion Exercise" (2015). Physical Therapy Faculty Publications. 54.
Published in Journal of Biomedical Optics, v. 20, no. 12, article 125006, p. 1-10.
Brad Henry, Mingjun Zhao, Yu Shang, Timothy Uhl, D. Travis Thomas, Eleftherios S. Xenos, Sibu P. Saha, and Guoqiang Vu, " Hybrid diffuse optical techniques for continuous hemodynamic measurement in gastrocnemius during plantar flexion exercise," Journal of Biomedical Optics, 20(12), 125006, (2015).
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