US Patent Number
A kit and method of non-destructively radiolabelling a biomolecule substrate by halogenation, including the steps of: a) reacting a secondary amine with a chlorinating agent to produce an N-chloro secondary amine, (b) reacting the N-chloro secondary amine with a salt of a radiolabelled halogen to produce a radiolabelled halogenating agent, (c) reacting a solution of the biomolecule substrate with the radiolabelled halogenating agent, and (d) recovering a radiohalogenated biomolecule from the reaction of step (c). The kit and method allow for more complete iodination with a lessening of side reactions such as decomposition of the biomolecule substrate to be labelled.
Board of Trustees of The University of Kentucky, Lexington, Ky.
Hussain, Anwar A. and Dittert, Lewis W., "Non-Destructive Method for Radiolabelling Biomolecules by Halogenation" (1995). Pharmaceutical Sciences Faculty Patents. 91.