US Patent Number
Camptothecin drugs are stabilized in their antitumor active lactone form by complexation with an oligonucleotide including RNA or catalytic RNA. The oligonucleotide-camptothecin drug complex may be incorporated within a macromolecular assembly including both viral and non-viral oligonucleotide vectors. The invention allows combination gene and camptothecin drug therapy.
University of Kentucky Research Foundation, Lexington, KY (US)
Burke, Thomas; Demir, Ayhan S.; Chavan, Ashok J.; and Yang, Danzhou, "Oligonucleotide Delivery Systems for Camptothecins" (2005). Pharmaceutical Sciences Faculty Patents. 80.