US Patent Number
The present invention is directed towards an artificial RNA nano structure comprising multiple external strands of RNA, each external strand comprising about 40-50 nucleotides; one internal strand of RNA comprising more than about 50 nucleotides; the internal strands and external strands assembled to form a triangle nanostructure, a square nanostructure, or a polygon nanostructure and a pRNA three-way junction (3WJ) motif at each vertex of the nanostructure. Such nanostructure can be provided in a composition together with an adjuvant for use in inducing the production of high affinity neutralizing antibodies or inhibitory antibodies, inducing the production of cytokines, inducing an immune response in a subject, or a combination thereof.
University of Kentucky Research Foundation, Lexington, KY (US)
Guo, Peixuan; Li, Hui; Khisamutdinov, Emil F.; and Jasinski, Daniel L., "RNA-Based Compositions and Adjuvants for Prophylactic and Therapeutic Treatment" (2019). Pharmaceutical Sciences Faculty Patents. 183.