US Patent Number
Provided herein are novel small-molecules that have use in the inhibition of Eis, which mediates kanamycin resistance in Mycobacterium tuberculosis. The presently-disclosed subject matter further includes a pharmaceutical composition including a small molecule inhibitor, as described herein, and a suitable pharmaceutical carrier. Methods of treating tuberculosis comprising administering to an individual an effective amount of the disclosed small molecule inhibitors to mediate kanamycin A resistance and treat tuberculosis are also provided.
University of Kentucky Research Foundation, Lexington, KY (US), The United States of America, as represented by the Secretary, Department of Health and Human Services, Rockville, MD (US)
Garneau-Tsodikova, Sylvie; Tsodikov, Oleg V.; and Posey, James E., "Eis Inhibitors" (2019). Pharmaceutical Sciences Faculty Patents. 180.