US Patent Number
Provided are bis-quaternary ammonium cyclophane compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.
University of Kentucky Research Foundation, Lexington, KY (US)
Crooks, Peter A.; Dwoskin, Linda P.; Zheng, Guangrong; Sumithran, Sangeetha; Allen, David; Zheng, Zhenfa; and Lockman, Paul, "Bis-Quaternary Ammonium Cyclophane Compounds that Interact with Neuronal Nicotinic Acetylcholine Receptors" (2017). Pharmaceutical Sciences Faculty Patents. 169.