US Patent Number
N-n-Alkylation of nicotine converts nicotine from an agonist into an antagonist specifically for neuronal nicotinic acetylcholine receptor subtypes mediating nicotine-evoked dopamine release. Conformationally restricted analogs exhibit both high affinity and selectivity at this site, and are able to access the brain due to their ability to act as substrates for the blood-brain barrier choline transporter.
University of Kentucky Research Foundation, Lexington, KY (US)
Crooks, Peter A.; Dwoskin, Linda P.; Ayers, Joshua; Grinevich, Vladimir; and Sumithran, Sangeetha, "Bis-Pyridino Containing Compounds for the Use in the Treatment of CNS Pathologies" (2013). Pharmaceutical Sciences Faculty Patents. 16.