US Patent Number
The invention relates to a novel method of administering the natural female sex hormones, 17 β- estradiol and progesterone, to achieve enhanced bioavailability thereof. The invention further relates to novel dosage forms of 17 β- estradiol and/or progesterone which are adapted for nasal administration, such as solutions, suspensions, gels and ointments. The dosage forms containing a combination of 17 β-estradiol and progesterone are particularly useful as contraceptives, while the dosage forms containing only one of the hormonal components find utility in the treatment of conditions such as menopause, menstrual disorders, etc., which are known to respond to administration of a natural or synthetic female hormone.
University of Kentucky Research Foundation, Lexington, Ky.
Hussain, Anwar A.; Hirai, Shinichiro; and Bawarshi, Rima, "Method of Administering Natural Female Sex Horomones" (1982). Pharmaceutical Sciences Faculty Patents. 143.