Positive-strand (+)RNA viruses are important and emerging pathogens of humans, animals, and plants. Upon infection, they induce the formation of specialized membranous replication organelles with unique lipid composition to facilitate robust virus replication. In this article, the authors discuss the proviral role of virus-induced membrane contact sites (vMCSs). The emerging picture is that vMCSs channel lipids to viral membranes and tune the lipid composition for optimal generation and functioning of replication organelles.

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Published in PLOS Pathogens, v. 12, no. 10, e1005912, p. 1-6.

© 2016 Nagy et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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This work was supported by National Science Foundation (MCB1517751) to PDN and the Netherlands Organisation for Scientific Research (NWO) (VENI-722.012.006) to JRPMS and (VICI-91812628) to FJMvK.