Positive-stranded RNA (+RNA) viruses exploit host cell machinery by subverting host proteins and membranes and altering cellular pathways during infection. To achieve robust replication, some +RNA viruses, such as poliovirus (PV), build special intracellular compartments, called viral replication organelles. A recent work from the Altan-Bonnett laboratory  gave new insights into the formation of poliovirus replication organelles, which are unique subcellular structures containing many individual replication complexes as a result of dynamic cellular membrane remodeling.
Digital Object Identifier (DOI)
Sasvari, Zsuzsanna and Nagy, Peter D., "Making of Viral Replication Organelles by Remodeling Interior Membranes" (2010). Plant Pathology Faculty Publications. 28.