US Patent Number
The invention relates to the use of nicotinic acid alkyl esters, especially myristyl nicotinate, to inhibit side effects associated with retinoic acid therapy. Also a part of the invention is a method for improving skin cell differentiation by administering the nicotinic acid alkyl ester in an amount sufficient to increase expression of caspase 14 and filaggrin. Deficiencies in expression of these molecules can be treated in this way as well.
University of Kentucky Research Foundation, Lexington, KY (US)
Jacobson, Elaine L.; Jacobson, Myron K.; Coyle, Russell; Kim, Hyuntae; and Coyle, Donna L., "Method for Alleviating Side Effects of Retinoic Acid Therapy and/or Improving Efficacy without Interfering with Efficacy" (2017). Pharmacology and Nutritional Sciences Faculty Patents. 51.