US Patent Number
The subject technology relates, in part, to a method of treating Alzheimer's Disease (AD), early-stage AD, elevated risk of AD, mild cognitive impairment (MCI), or other forms of age-related cognitive decline in a subject in need thereof by administering to the subject a molecule that promotes calcium-release stabilization in ryanodine receptors (RyRs) and/or inosital triphosphate receptors (InsP3Rs) in brain cells. Diagnostic methods using calcium-release stabilizing immunophilins, junctophilins or calmodulin are also disclosed.
University of Kentucky Research Foundation, Lexington, KY (US)
Landfield, Philip W.; Gant, John C.; Blalock, Eric M.; Chen, Kuey-Chu; Thibault, Olivier; and Porter, Nada M., "Methods for Diagnosing and Treating Alzheimer's Disease (AD) Using the Molecules that Stabilize Intracellular Calcium (CA2+) Release" (2016). Pharmacology and Nutritional Sciences Faculty Patents. 50.