US Patent Number
2,4-disulfonyl α-phenyl-tert-butyl nitrone and its pharmaceutically acceptable salts are disclosed. These materials are useful as pharmaceutical agents for oral or parenteral, e.g. intravenous administration to patients suffering from acute central nervous system oxidation as occurs in a stroke or from gradual central nervous system oxidation which can exhibit itself as progressive central nervous system function loss. The materials are also used to ameliorate the side effects of oxidative-damage causing antineoplastic disease treatments.
Oklahoma Medical Research Foundation, Oklahoma City, Okla., University of Kentucky Research Foundation, Lexington, Ky.
Carney, John M., "2,4-Disulfonyl Phenyl Butyl Nitrone, Its Salt and Their Use as Pharmaceuticals" (1996). Pharmacology and Nutritional Sciences Faculty Patents. 26.