Loss of epithelial cell polarity and inflammation are hallmarks of breast cancer development. Although the association between the disruption of tissue polarity and inflammation has been demonstrated, we know little about how these two events are coupled. Using the 3D co-culture model of mammary epithelial cells and monocytes, a recent study reveals a link between disruption of epithelial polarity and monocytes infiltration.

Document Type


Publication Date


Notes/Citation Information

Published in Macrophage, v. 4, e1521, p. 1-3.

© 2017 The Authors.

Licensed under a Creative Commons Attribution 4.0 International License which allows users including authors of articles to copy and redistribute the material in any medium or format, in addition to remix, transform, and build upon the material for any purpose, even commercially, as long as the author and original source are properly cited or credited.

Digital Object Identifier (DOI)


Funding Information

The study was supported by start-up funding from the Markey Cancer Center and funding support from the American Heart Association (12SDG8600000 to R.X.) and U.S. Department of Defense (W81XWH-15-1-0052 to R.X.).