Loss of epithelial cell polarity and inflammation are hallmarks of breast cancer development. Although the association between the disruption of tissue polarity and inflammation has been demonstrated, we know little about how these two events are coupled. Using the 3D co-culture model of mammary epithelial cells and monocytes, a recent study reveals a link between disruption of epithelial polarity and monocytes infiltration.
Digital Object Identifier (DOI)
The study was supported by start-up funding from the Markey Cancer Center and funding support from the American Heart Association (12SDG8600000 to R.X.) and U.S. Department of Defense (W81XWH-15-1-0052 to R.X.).
Xu, Ren, "Mammary Epithelial Polarity and Macrophage Infiltration" (2017). Pharmacology and Nutritional Sciences Faculty Publications. 59.