MiR-107 is a microRNA (miRNA) that we reported previously to have decreased expression in the temporal cortical gray matter early in the progression of Alzheimer's disease (AD). Here we study a new group of well-characterized human temporal cortex samples (N=19). MiR-107 expression was assessed, normalized to miR-124 and let-7a. Correlation was observed between decreased miR-107 expression and increased neuritic plaque counts (P< 0.05) and neurofibrillary tangle counts (P< 0.02) in adjacent brain tissue. Adjusted miR-107 and BACE1 mRNA levels tended to correlate negatively (trend with regression P< 0.07). In sum, miR-107 expression tends to be lower relative to other miRNAs as AD progresses.
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This study was supported by grants R01 NS061933 and K08 NS050110 from the National Institutes of Health, Bethesda, MD, and a New Investigator Research Grant from the Alzheimer Association.
Nelson, Peter T. and Wang, Wang-Xia, "MiR-107 is Reduced in Alzheimer's Disease Brain Neocortex: Validation Study" (2010). Pathology and Laboratory Medicine Faculty Publications. 24.