US Patent Number
A method of protecting a cell includes inhibiting an inflammasome, MyD88, IL-18, VDAC1, VDAC2, caspase-8, and/or NFκB of the cell. Administering an inhibitor of MyD88, IL-18, VDAC1, VDAC2, caspase-8, and/or NFκB can protect the cell from Alu-RNA-induced degeneration. Protecting a cell, such as an retinal pigment epithelium (RPE), can be therapeutically useful in the context of age-related macular degeneration and geographic atrophy.
University of Kentucky Research Foundation, Lexington, KY (US)
Ambati, Jayakrishna and Tarallo, Valeria, "Protection of Cells from Alu-RNA-Induced Degeneration and Inhibitors for Protecting Cells" (2016). Ophthalmology and Visual Science Faculty Patents. 21.