Background and Objective

Adiponectin is produced by adipose cells and is considered an anti‐inflammatory molecule. In contrast, C‐reactive protein (CRP) has been identified as a hallmark of systemic inflammation and used as a risk marker of cardiovascular disease (CVD). Of interest was the relationship of these two biomarkers to oral health and CVD risk.

Material and Methods

This investigation examined these two molecules in serum and unstimulated whole saliva of patients within 48 h of an acute myocardial infarction (AMI) compared to control subjects. We hypothesized a differential response in these biomolecules resulting from the heart attack that would be affected by both the body mass index and oral health characteristics of the individuals.


Significantly lower adiponectin levels were observed in the serum of patients with AMI. Serum adiponectin in both groups and salivary adiponectin in patients with AMI decreased with increasing body mass index. Oral health was significantly worse in patients with AMI, and both serum and salivary adiponectin were elevated with better oral health in control subjects. Serum CRP levels were increased in patients with AMI regardless of their oral health, and both serum and salivary CRP were significantly elevated in S‐T wave elevated patients with MI.


These initial data provide evidence relating obesity and oral health to salivary and serum analyte levels that occur in association with cardiac events. Relationships have been described between CVD risk and periodontal disease. Additionally, various systemic inflammatory biomarkers appear to reflect both the CVD risk and the extent/severity of periodontitis. Our findings indicated that oral health and obesity contribute to altering levels of these salivary and serum analytes in association with cardiac events. The potential that serum and/or salivary biomarkers could aid in evaluating CVD risk requires knowledge regarding how the oral health of the individual would impact the effectiveness of these biological measures.

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Publication Date


Notes/Citation Information

Published in Journal of Periodontal Research, v. 52, issue 3, p. 419-427.

© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

The copyright holder has granted the permission for posting the article here.

This is the peer reviewed version of the following article: Ebersole, J. L., Kryscio, R. J., Campbell, C., Kinane, D. F., McDevitt, J., ... Miller, C. S. (2017). Salivary and serum adiponectin and C‐reactive protein levels in acute myocardial infarction related to body mass index and oral health. Journal of Periodontal Research, 52(3), 419-427, which has been published in final form at https://doi.org/10.1111/jre.12406. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

The document available for download is the authors' post-peer-review final draft of the article. Its title is "Salivary and Serum Adiponectin and CRP Levels in Acute Myocardial Infarction Related to BMI and Oral Health."

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Funding Information 

This study was supported by grants from the National Institute of Health P20 GM 103538, and U01 DE017793 the and partially supported by the Clinical and Translational Science Award UL1 TL000117 to the University of Kentucky.