Abstract
INTRODUCTION: Recent growth in the functionality and use of technology has prompted an increased interest in the potential for remote or decentralized clinical trials in dementia. There are many potential benefits associated with decentralized medication trials, but we currently lack specific recommendations for their delivery in the dementia field.
METHODS: A modified Delphi method engaged an expert panel to develop recommendations for the conduct of decentralized medication trials in dementia prevention. A working group of researchers and clinicians with expertise in dementia trials further refined the recommendations.
RESULTS: Overall, the recommendations support the delivery of decentralized trials in dementia prevention provided adequate safety checks and balances are included. A total of 40 recommendations are presented, spanning aspects of decentralized clinical trials, including safety, dispensing, outcome assessment, and data collection.
DISCUSSION: These recommendations provide an accessible, pragmatic guide for the design and conduct of remote medication trials for dementia prevention.
Document Type
Article
Publication Date
7-2024
Digital Object Identifier (DOI)
https://doi.org/10.1002/alz.13891
Funding Information
Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment (ISTAART); Clinical Trials Advancement and Methods Professional Interest Area
Repository Citation
Howard, Leanne; Abdelnour, Carla; Abner, Erin; Allegri, Ricardo F.; Dodge, Hiroko H.; Gauthier, Serge; Hoyos, Camilla M.; Jicha, Gregory; Kehoe, Patrick G.; Mummery, Catherine J.; Ogunniyi, Adesola; Scarmeas, Nikolaos; Chen, Xiaoying; Titiner, Jodie R.; Weber, Christopher R.; and Peters, Ruth, "Decentralized clinical trials for medications to reduce the risk of dementia: Consensus report and guidance" (2024). Neurology Faculty Publications. 112.
https://uknowledge.uky.edu/neurology_facpub/112
Included in
Developmental Neuroscience Commons, Epidemiology Commons, Geriatrics Commons, Health Policy Commons, Molecular and Cellular Neuroscience Commons, Neurology Commons, Psychiatry and Psychology Commons
Notes/Citation Information
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2024 The Author(s). Alzheimer’s & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer’s Association.