US Patent Number
The present invention provides a monoclonal anti-idiotype antibody 11D10 that elicits an immune response against a specific epitope of a high molecular weight mucin of human milk fat globule (HMFG) and a hybridoma that produces 11D10. The hybridoma that produces 11D10 was selected by specific procedures. 11D10 induces an immunological response to HMFG in nice, rabbits, monkeys and patients with advanced HMFG-associated tumors. This invention provides compositions derived from polynucleotide sequences encoding the variable light and/or variable heavy regions of monoclonal anti-idiotype antibody 11D10, as well as polypeptides encoded thereby. The invention also provides compositions which can be used in the detection or treatment of HMFG-associated tumors.
The Board of Trustees of the University of Kentucky, Lexington, KY (US)
Chatterjee, Malaya; Foon, Kenneth A.; and Chatterjee, Sunil K., "Murine Monoclonal Anti-Idiotype Antibody 11D10 and Methods of Use Thereof" (2005). Microbiology, Immunology and Molecular Genetics Faculty Patents. 7.