In this review, we trace the concept and potential functional role of regulatory idiotypes in the immune response to human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus, and hepatitis C virus (HCV). A major idiotype involved in these viral infections is recognized and defined by a murine monoclonal antibody (1F7). Antibodies expressing the idiotype defined by 1F7 are dominant in HIV-1 infection and are also found on many broadly neutralizing antibodies against HIV-1. This regulatory idiotypic axis offers opportunities for exploitation in vaccine development for HIV-1, HCV, and other chronic viral infections.
Digital Object Identifier (DOI)
MP is supported by a postdoctoral fellowship from the Canadian Institutes of Health Research (CIHR).
Muller, Sybille; Parsons, Matthew S.; Kohler, Heinz; and Grant, Michael, "The Significance of a Common Idiotype (1F7) on Antibodies Against Human Immune Deficiency Virus Type 1 and Hepatitis C Virus" (2016). Microbiology, Immunology, and Molecular Genetics Faculty Publications. 89.