An understanding of the pathogenesis and pathophysiology of Lyme disease is key to the ultimate care of patients with Lyme disease. To better understand the various mechanisms underlying the infection caused by Borrelia burgdorferi, the Pathogenesis and Pathophysiology of Lyme Disease Subcommittee was formed to review what is currently known about the pathogenesis and pathophysiology of Lyme disease, from its inception, but also especially about its ability to persist in the host. To that end, the authors of this report were assembled to update our knowledge about the infectious process, identify the gaps that exist in our understanding of the process, and provide recommendations as to how to best approach solutions that could lead to a better means to manage patients with persistent Lyme disease.

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Published in Frontiers in Medicine, v. 8, article 643235.

© 2021 Donta, States, Adams, Bankhead, Baumgarth, Embers, Lochhead and Stevenson

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This report is a condensed version of the full report that appears on the HHS TBDWG website, and has the permission of the HHS designated officer assigned to this working group.