Abstract
Polychlorinated biphenyls (PCBs) are persistent environmental organic pollutants known to have detrimental health effects. Using a mouse model, we previously demonstrated that PCB126 exposure before and during pregnancy and throughout the perinatal period adversely affected offspring glucose tolerance and/or body composition profiles. The purpose of this study was to investigate the glucose tolerance and body composition of offspring born to dams exposed to PCB126 during the nursing period only. Female ICR mice were bred, and half of the dams were exposed to either vehicle (safflower oil) or 1 μmole PCB126 per kg of body weight via oral gavage on postnatal days (PND) 3, 10, and 17 (n = 9 per group). Offspring body weight, lean and fat mass, and glucose tolerance were recorded every three weeks. PCB126 treatment did not alter dam nor offspring body weight (p > 0.05). PCB126-exposed male and female offspring displayed normal body composition (p > 0.05) relative to vehicle-exposed offspring. However, both male and female offspring that were exposed to PCB126 during the nursing period had significantly impaired glucose tolerance at 3 and 9 weeks of age (p < 0.05). At 6 and 12 weeks of age, no impairments in glucose tolerance existed in offspring (p > 0.05). Our current study demonstrates that exposure to PCB126 through the mother’s milk does not affect short- or long-term body composition but impairs glucose tolerance in the short-term.
Document Type
Article
Publication Date
3-2023
Digital Object Identifier (DOI)
https://doi.org/10.3389/fendo.2023.1085958
Funding Information
Research reported was supported by the National Institute of Environmental Health Sciences (P42ES007380) and the National Institute of General Medical Sciences (P20GM103527). BR was supported by the Southern Regional Education Board Doctoral Scholars Program. KS was supported by the Undergraduate Summer Research Training Program in Cardiovascular Research funded by the American Heart Association (17UFEL33490002). MW was supported by the Summer Undergraduate Research in Environmental Health Sciences Program funded by the National Institute of Environmental Health Sciences (R25ES027684). LR was supported by an American Heart Association Postdoctoral Fellowship (15POST25110002). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Repository Citation
Rice, Brittany Breon; Sammons, Keegan W.; Tenlep, Sara Y. Ngo; Weltzer, Madeline T.; Reynolds, Leryn J.; Rashid, Cetewayo S.; Swanson, Hollie I.; and Pearson, Kevin J., "Exposure to PCB126 during the nursing period reversibly impacts early-life glucose tolerance" (2023). Markey Cancer Center Faculty Publications. 334.
https://uknowledge.uky.edu/markey_facpub/334
Notes/Citation Information
© 2023 Rice, Sammons, Ngo Tenlep, Weltzer, Reynolds, Rashid, Swanson and Pearson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.