Blinatumomab, a bispecific T-cell engager monoclonal antibody used to manage Philadelphia chromosome-negative relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL) can be used to treat patients by inducing graft versus leukemia reaction post allogeneic hematopoietic stem cell transplantation, a feature which it was post allogeneic bone marrow transplantation, a feature which this drug was not aimed to do.
Digital Object Identifier (DOI)
Khan, Muhammad Waqas and Gul, Zartash, "Blinatumomab May Induce Graft Versus Host Leukemia in Patients with Pre-B ALL Relapsing After Hematopoietic Stem Cell Transplant" (2016). Internal Medicine Faculty Publications. 103.