Oxidized LDL induces changes in several facets of the immune system, although the relationships between these facets and their contributions to atherogenesis have yet to be fully elucidated. A report in this issue of the JCI provides a novel demonstration of the adaptive immune system influencing the production of natural antibodies. The results demonstrate that injection of malondialdehyde-modified LDL promotes a Th2 response that in turn increases the titers of the natural antibody T15/EO6, which recognizes the oxidized phospholipid POVPC. Atherosclerotic lesion size in LDL receptor–deficient mice is reduced as a consequence of the increase in natural antibody titers, and IL-5 is identified as the link between the adaptive and natural immune systems.
Digital Object Identifier (DOI)
Daugherty, Alan; Rateri, Debra L.; and King, Victoria L., "IL-5 Links Adaptive and Natural Immunity in Reducing Atherosclerotic Disease" (2004). Gill Heart & Vascular Institute Faculty Publications. 29.