US Patent Number
7629160
Publication Date
12-8-2009
Abstract
It is the object of the current invention to provide methods and compositions relating to the expression of vankyrin proteins in cell lines to increase their viability, longevity and capacity for protein production. The inventors have discovered that the expression of P-ank-1 and I2-ank-3 proteins in cell culture has increased the cells' longevity and capacity for endogenous and/or heterologous target protein production. Specifically, the present invention relates to the enhanced expression of endogenous and/or heterologous target proteins/polypeptides in recombinant cells that are also expressing P-ank-1 and/or I2-ank-3 protein compared to expression host cells that are not expressing P-ank-1 and/or I2-ank-3 protein.
Assignees
University of Kentucky Research Foundation, Lexington, KY (US)
Application Number
11/016,871
Filing Date
12/21/2004
Recommended Citation
Webb, Bruce A. and Kroemer, Jeremy, "Vectors and Methods for Enhanced Cell Longevity and Protein Expression" (2009). Entomology Faculty Patents. 3.
https://uknowledge.uky.edu/entomology_patents/3