Abstract
Antithrombotic therapy is a delicate balance between the benefits of preventing a thrombotic event and the risks of inducing a major bleed. Traditional approaches have included antiplatelet and anticoagulant medications, require careful dosing and monitoring, and all carry some risk of bleeding. In recent years, several new targets have been identified, both in the platelet and coagulation systems, which may mitigate this bleeding risk. In this review, we briefly describe the current state of antithrombotic therapy, and then present a detailed discussion of the new generation of drugs that are being developed to target more safely existing or newly identified pathways, alongside the strategies to reverse direct oral anticoagulants, showcasing the breadth of approaches. Combined, these exciting advances in antithrombotic therapy bring us closer than we have ever been to the “holy grail” of the field, a treatment that separates the hemostatic and thrombotic systems, preventing clots without any concurrent bleeding risk.
Document Type
Article
Publication Date
10-2023
Digital Object Identifier (DOI)
https://doi.org/10.3389/fcvm.2023.1272971
Funding Information
The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.
Repository Citation
Sim, Martha M. S.; Shiferawe, Semekidus; and Wood, Jeremy P., "Novel strategies in antithrombotic therapy: targeting thrombosis while preserving hemostasis" (2023). Saha Cardiovascular Research Center Faculty Publications. 59.
https://uknowledge.uky.edu/cvrc_facpub/59
Notes/Citation Information
© 2023 Sim, Shiferawe and Wood. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.