An in vitro model of bacterial biofilms on rigid gas-permeable contact lenses (RGPLs) was developed to challenge oral epithelial cells. This novel model provided seminal data on oral biofilm-host cell interactions, and with selected bacteria, the biofilms were more effective than their planktonic counterparts at stimulating host cell responses.
Digital Object Identifier (DOI)
This work was supported by USPHS grant R21 DE018177 from the National Institute for Dental and Craniofacial Research.
Peyyala, Rebecca; Kirakodu, Sreenatha S.; Novakova, Lucia; and Ebersole, Jeffrey L., "Epithelial Interleukin-8 Responses to Oral Bacterial Biofilms" (2011). Center for Oral Health Research Faculty Publications. 4.