The efficacy of a novel synthetic antimicrobial peptide (WLBU2) was evaluated against three oral microorganisms (grown planktonically): Streptococcus gordonii, Fusobacterium nucleatum, and Porphyromonas gingivalis. WLBU2 killed all three species, with F. nucleatum being the most susceptible. WLBU2 also reduced the bacterial burden of S. gordonii and F. nucleatum biofilms.

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Published in Antimicrobial Agents and Chemotherapy, v. 51, no. 5, p. 1837–1839.

Copyright © 2007, American Society for Microbiology. All Rights Reserved.

The copyright holders have granted the permission for posting the article here.

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This work was supported by a University of Kentucky research support grant and by Kentucky Science and Technology Corporation/Kentucky Science and Engineering Foundation grant KSEF-47-RDE-004.