Title

Increasing Adipocyte Lipoprotein Lipase Improves Glucose Metabolism in High Fat Diet-induced Obesity

Authors

R. Grace Walton, University of Kentucky
Beibei Zhu, University of Kentucky
Resat Unal, Mugla Sitki Kocman University, Turkey
Michael Spencer, University of Kentucky
Manjula Sunkara, University of Kentucky
Andrew J. Morris, University of Kentucky
Richard Charnigo, University of Kentucky
Wendy Katz, University of Kentucky
Alan Daugherty, University of Kentucky
Deborah A. Howatt, University of Kentucky
Philip A. Kern, University of Kentucky
Brian S. Finlin, University of Kentucky

Abstract

Background: Lipoprotein lipase regulates fat uptake into adipose tissue.

Results: A mouse model with increased adipose tissue lipoprotein lipase has improved glucose metabolism when challenged with a high fat diet.

Conclusion: Increasing adipose tissue lipoprotein lipase improves adipose tissue function.

Significance: Adipose tissue lipoprotein lipase protects against obesity-induced glucose and insulin intolerance.

Document Type

Article

Publication Date

5-1-2015

Digital Object Identifier (DOI)

10.1074/jbc.M114.628487

Repository Citation

Walton, R. Grace; Zhu, Beibei; Unal, Resat; Spencer, Michael; Sunkara, Manjula; Morris, Andrew J.; Charnigo, Richard; Katz, Wendy; Daugherty, Alan; Howatt, Deborah A.; Kern, Philip A.; and Finlin, Brian S., "Increasing Adipocyte Lipoprotein Lipase Improves Glucose Metabolism in High Fat Diet-induced Obesity" (2015). Clinical and Translational Science Faculty Publications. 20.
https://uknowledge.uky.edu/ccts_facpub/20