Background: Lipoprotein lipase regulates fat uptake into adipose tissue.
Results: A mouse model with increased adipose tissue lipoprotein lipase has improved glucose metabolism when challenged with a high fat diet.
Conclusion: Increasing adipose tissue lipoprotein lipase improves adipose tissue function.
Significance: Adipose tissue lipoprotein lipase protects against obesity-induced glucose and insulin intolerance.
Digital Object Identifier (DOI)
Walton, R. Grace; Zhu, Beibei; Unal, Resat; Spencer, Michael; Sunkara, Manjula; Morris, Andrew J.; Charnigo, Richard; Katz, Wendy; Daugherty, Alan; Howatt, Deborah A.; Kern, Philip A.; and Finlin, Brian S., "Increasing Adipocyte Lipoprotein Lipase Improves Glucose Metabolism in High Fat Diet-induced Obesity" (2015). Clinical and Translational Science Faculty Publications. 20.