Abstract
The direct action of bacterial lipopolysaccharides (LPS) endotoxin was shown to enhance synaptic transmission and hyperpolarize the membrane potential at low doses, but block glutamatergic receptors and decrease observable spontaneous events at a high dosage. The dosage effects are LPS type specific. The hyperpolarization is not due to voltage-gated potassium channels or to activation of nitric oxide synthase (NOS). The effects are induced directly by LPS, independent of an immune response.
Document Type
Article
Publication Date
3-28-2019
Digital Object Identifier (DOI)
https://doi.org/10.1016/j.heliyon.2019.e01430
Funding Information
This work was supported by personal funds (R.L.C.) and a “Sustaining Excellence-2014” competition grant from the Howard Hughes Medical Institute (Grant #52008116 ) awarded to the University of Kentucky (VM Cassone, PI).
Related Content
Data associated with this study has been deposited at osf.io/psv9m (Cooper, Robin. 2018. “LPS -NMJ-Drosophila Data Bank.” OSF. September 26).
Repository Citation
Cooper, Robin L.; McNabb, Micaiah; and Nadolski, Jeremy, "The Effects of Bacterial Endotoxin LPS on Synaptic Transmission at the Neuromuscular Junction" (2019). Biology Faculty Publications. 179.
https://uknowledge.uky.edu/biology_facpub/179
Included in
Bacteria Commons, Biology Commons, Neuroscience and Neurobiology Commons, Physiology Commons
Notes/Citation Information
Published in Heliyon, v. 5, issue 3, e01430, p. 1-17.
© 2019 The Authors. Published by Elsevier Ltd.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).