US Patent Number
10,415,039
Publication Date
9-17-2019
Abstract
The present invention provides, among other things, oligonucleotide modulators of human 5′-HT2C receptor (HTR2C) and improved methods and composition for treating HTR2C-related diseases, disorders or conditions based on such modulators. In particular, oligonucleotides modulators according to the invention target specific regions in the Exon V/Intron V junction of the human HTR2C pre-mRNA and drive expression of HTR2C Vb splice isoform, leading to increased generation of non-edited strong HTR2C receptor and enhanced serotonin receptor activity.
Assignees
Shire Human Genetic Therapies, Inc., Lexington, MA (US)
Application Number
15/400,698
Filing Date
01/06/2017
Recommended Citation
Stamm, Stefan; Shen, Manli; and Josiah, Serene, "Antisense Oligonucleotide Modulators of Serotonin Receptor 2C and Uses Thereof" (2019). Molecular and Cellular Biochemistry Faculty Patents. 26.
https://uknowledge.uky.edu/biochem_patents/26
