Sepsis remains a significant medical problem. TNFα is a central cytokine in sepsis pathophysiology. We conducted a phase IIa trial in patients with severe sepsis to assess the safety and tolerability of an intravenously infused ovine-derived polyclonal anti-TNFα Fab fragment (AZD9773).
Digital Object Identifier (DOI)
Morris, Peter E.; Zeno, Brian; Bernard, Andrew C.; Huang, Xiangning; Simonson, Steven G.; and Bernard, Gordon R., "Safety and tolerability of an ovine-derived polyclonal anti-TNFα Fab fragment (AZD9773) in patients with severe sepsis" (2011). Surgery Presentations. Paper 1.