US Patent Number
The present invention relates to Par-4 mutants which cause apoptosis in cancer cells which are sensitive to Par-4 and also induce apoptosis in cancer cells which are resistant to Par-4. The present invention also relates to methods of using the Par-4 mutant to treat certain cancers, as well as to kits, vectors, and polypeptides for same.
University of Kentucky Research Foundation, Lexington, KY (US)
Rangnekar, Vivek M., "Identification of a Unique Core Domain of Par-4 Sufficient for Selective Apoptosis Induction in Cancer Cells" (2010). Radiation Medicine Faculty Patents. Paper 1.