Abstract
Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme that catalyzes the conversion of prostaglandin (PG)H2 to PGE2. Proinflammatory stimuli markedly increase levels of mPGES-1 expression both in vivo and in vitro. mPGES-1 knockout studies and animal models of inflammatory arthritis also provide a strong basis for the contribution of mPGES-1 in the increased local production of PGE2 observed in inflammatory arthritis. The focus of this article is to review some recent advances in our understanding of mechanisms specific to the regulation of inducible mPGES-1 in inflammatory arthritis.
Document Type
Commentary
Publication Date
4-6-2005
Digital Object Identifier (DOI)
http://dx.doi.org/10.1186/ar1748
Repository Citation
Sampey, Annaleise V.; Monrad, Seetha; and Crofford, Leslie J., "Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2" (2005). Internal Medicine Faculty Publications. 26.
https://uknowledge.uky.edu/internalmedicine_facpub/26
Notes/Citation Information
Published in Arthritis Research & Therapy, v. 7, no. 3, pp. 114-17.
© 2005 BioMed Central Ltd
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.