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Submissions from 2021

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An Empirical Pipeline for Personalized Diagnosis of Lafora Disease Mutations, M. Kathryn Brewer, Maria Machio-Castello, Rosa Viana, Jeremiah L. Wayne, Andrea Kuchtová, Zoe R. Simmons, Sarah Sternbach, Sheng Li, Maria Adelaida García-Gimeno, Jose M. Serratosa, Pascual Sanz, Craig W. Vander Kooi, and Matthew S. Gentry

Submissions from 2020

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Polyglucosan Body Structure in Lafora Disease, M. Kathryn Brewer, Jean-Luc Putaux, Alberto Rondon, Annette M. Uittenbogaard, Mitchell A. Sullivan, and Matthew S. Gentry

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Calcineurin, Trevor P. Creamer

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NEK1 Phosphorylation of YAP Promotes Its Stabilization and Transcriptional Output, Md Imtiaz Khalil, Ishita Ghosh, Vibha Singh, Jing Chen, Haining Zhu, and Arrigo De Benedetti

Submissions from 2018

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Insulin-Degrading Enzyme Is Not Secreted From Cultured Cells, Eun Suk Song, David W. Rodgers, and Louis Hersh

Submissions from 2017

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Structure and Specificity of a Permissive Bacterial C-Prenyltransferase, Sherif I. Elshahawi, Hongnan Cao, Khaled A. Shaaban, Larissa V. Ponomareva, Thangaiah Subramanian, Mark L. Farman, H. Peter Spielmann, George N. Phillips Jr., Jon S. Thorson, and Shanteri Singh

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Down Syndrome: Age-Dependence of PiB Binding in Postmortem Frontal Cortex Across the Lifespan, Harry LeVine III, H. Peter Spielmann, Sergey V. Matveev, Francesca Macchiavello Cauvi, M. Paul Murphy, Tina L. Beckett, Katie McCarty, Ira T. Lott, Eric Doran, Frederick A. Schmitt, and Elizabeth Head

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Quaternary Interactions and Supercoiling Modulate the Cooperative DNA Binding of AGT, Manana Melikishvili and Michael G. Fried

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Mechanism-Informed Refinement Reveals Altered Substrate-Binding Mode for Catalytically Competent Nitroreductase, Warintra Pitsawong, Chad A. Haynes, Ronald L. Koder, David W. Rodgers, and Anne-Frances Miller

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1H, 15N, and 13C Chemical Shift Assignments of the Regulatory Domain of Human Calcineurin, Dinesh K. Yadav, Sri Ramya Tata, John Hunt, Erik C. Cook, Trevor P. Creamer, and Nicholas C. Fitzkee

Submissions from 2016

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Targeting an Essential GTPase Obg for the Development of Broad-Spectrum Antibiotics, Josephine A. Bonventre, Ryszard A. Zielke, Konstantin V. Korotkov, and Aleksandra E. Sikora

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P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer, Hira Lal Goel, Bryan Pursell, Leonard D. Shultz, Dale L. Greiner, Rolf A Brekken, Craig W. Vander Kooi, and Arthur M. Mercurio

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Mycosins Are Required for the Stabilization of the ESX-1 and ESX-5 Type VII Secretion Membrane Complexes, Vincent J. C. van Winden, Roy Ummels, Sander R. Piersma, Connie R. Jiménez, Konstantin V. Korotkov, Wilbert Bitter, and Edith N. G. Houben

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Structures of EccB1 and EccD1 from the Core Complex of the Mycobacterial ESX-1 Type VII Secretion System, Jonathan Mark Wagner, Sum Chan, Timothy J. Evans, Sara Kahng, Jennifer Kim, Mark A. Arbing, David Eisenberg, and Konstantin V. Korotkov

Submissions from 2015

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Mechanistic Insights into Glucan Phosphatase Activity against Polyglucan Substrates, David A. Meekins, Madushi Raththagala, Kyle D. Auger, Benjamin D. Turner, Diana Santelia, Oliver Kötting, Matthew S. Gentry, and Craig W. Vander Kooi

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Structural Mechanism of Laforin Function in Glycogen Dephosphorylation and Lafora Disease, Madushi Raththagala, M. Kathryn Brewer, Matthew W. Parker, Amanda R. Sherwood, Brian K. Wong, Simon Hsu, Travis M. Bridges, Bradley C. Paasch, Lance M. Hellman, Satrio Husodo, David A. Meekins, Adam O. Taylor, Benjamin D. Turner, Kyle D. Auger, Vikas V. Dukhande, Srinivas Chakravarthy, Pascual Sanz, Virgil L. Woods Jr., Sheng Li, Craig Vander Kooi, and Matthew S. Gentry

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An Extended Polyanion Activation Surface in Insulin Degrading Enzyme, Eun Suk Song, Mehmet Ozbil, Tingting Zhang, Michael Sheetz, David Lee, Danny Tran, Sheng Li, Rajeev Prabhakar, Louis B. Hersh, and David W. Rodgers

Submissions from 2014

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Expression, Purification and Characterization of Soluble Red Rooster Laforin as a Fusion Protein in Escherichia Coli, M. Kathryn Brewer, Satrio Husodo, Vikas V. Dukhande, Mary Beth Johnson, and Matthew S. Gentry

Submissions from 2013

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Thermodynamics of Binding by Calmodulin Correlates with Target Peptide α-Helical Propensity, Tori B. Dunlap, Jessime M. Kirk, Emily A. Pena, Meghan S. Yoder, and Trevor P. Creamer

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Assembly of the type II secretion system such as found in Vibrio cholerae depends on the novel Pilotin AspS, Rhys A. Dunstan, Eva Heinz, Lakshmi C. Wijeyewickrema, Robert N. Pike, Anthony W. Purcell, Timothy J. Evans, Judyta Praszkier, Roy M. Robins-Browne, Richard A. Strugnell, Konstantin V. Korotkov, and Trevor Lithgow

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Functional Integration of the Conserved Domains of Shoc2 Scaffold, Myoungkun Jeoung, Lina Abdelmoti, Eun Ryoung Jang, Craig W. Vander Kooi, and Emilia Galperin

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Phosphorylation of Calcineurin at a novel serine-proline rich region orchestrates hyphal growth and virulence in Aspergillus fumigatus, Praveen R. Juvvadi, Christopher Gehrke, Jarrod R. Fortwendel, Frédéric Lamoth, Erik J. Soderblom, Erik C. Cook, Michael A. Hast, Yohannes G. Asfaw, M. Arthur Moseley, Trevor P. Creamer, and William J. Steinbach

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Dimerization of the glucan phosphatase laforin requires the participation of cysteine 329, Pablo Sánchez-Martín, Madushi Raththagala, Travis M. Bridges, Satrio Husodo, Matthew S. Gentry, Pascual Sanz, and Carlos Romá-Mateo

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Pyrvinium pamoate changes alternative splicing of the serotonin receptor 2C by influencing its RNA structure, Manli Shen, Stanislav Bellaousov, Michael Hiller, Pierre de La Grange, Trevor O. Creamer, Orit Malina, Ruth Sperling, David H. Mathews, Peter Stoilov, and Stefan Stamm

Submissions from 2012

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Lesion-Specific DNA-Binding and Repair Activities of Human O⁶-Alkylguanine DNA Alkyltransferase, Manana Melikishvili and Michael G. Fried