An in vitro model of bacterial biofilms on rigid gas-permeable contact lenses (RGPLs) was developed to challenge oral epithelial cells. This novel model provided seminal data on oral biofilm-host cell interactions, and with selected bacteria, the biofilms were more effective than their planktonic counterparts at stimulating host cell responses.
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This work was supported by USPHS grant R21 DE018177 from the National Institute for Dental and Craniofacial Research.
Peyyala, Rebecca; Kirakodu, Sreenatha S.; Novakova, Lucia; and Ebersole, Jeffrey L., "Epithelial Interleukin-8 Responses to Oral Bacterial Biofilms" (2011). Center for Oral Health Research Faculty Publications. Paper 4.