The efficacy of a novel synthetic antimicrobial peptide (WLBU2) was evaluated against three oral microorganisms (grown planktonically): Streptococcus gordonii, Fusobacterium nucleatum, and Porphyromonas gingivalis. WLBU2 killed all three species, with F. nucleatum being the most susceptible. WLBU2 also reduced the bacterial burden of S. gordonii and F. nucleatum biofilms.
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This work was supported by a University of Kentucky research support grant and by Kentucky Science and Technology Corporation/Kentucky Science and Engineering Foundation grant KSEF-47-RDE-004.
Novak, Karen F.; Diamond, William J.; Kirakodu, Sreenatha S.; Peyyala, Rebecca; Anderson, Kimberly W.; Montelaro, Ronald C.; and Mietzner, Timothy A., "Efficacy of the De Novo-Derived Antimicrobial Peptide WLBU2 against Oral Bacteria" (2007). Center for Oral Health Research Faculty Publications. Paper 3.