US Patent Number
An improved method for diagnosing a disease comprising detecting a disease-specific biochemical marker macromolecule within a sample of extracted cerebral spinal fluid or serum is disclosed. In particular, a radioactively labeled photoaffinity probe is used to diagnose a disease. For instance, Alzheimer's disease can be diagnosed by detecting a disease-specific protein having a molecular weight of about 42,000 daltons, i.e., glutamine synthetase. Also included is a method for detecting other disease states, such as cancer, by detecting the presence or absence of specific nucleotide binding proteins.
University of Kentucky Research Foundation, Lexington, Ky.
Haley, Boyd E., "Detection of Alzheimer's Disease and Other Diseases Using an Improved Photoaffinity Labeling Method" (1995). Chemistry Faculty Patents. Paper 27.